Development Of X-ray Visible Polymers Via In Situ Iodination-crosslinking For Non-invasive Real Time Imaging
Project Description :

The invention concerns facile, one step, development of biodegradable, cytocompatible radiopaque material comprising of iodine, unsaturated olefinic crosslinker with aldehyde groups and polymer with amine/amide functionalities. said radiopaque polymer can be variously fabricated into fibers, beads, foams, gel, powder, and the like for diverse biomedical applications. there is a high demand for non-invasive monitoring of implants upon insertion into the body. x-ray provides a low cost solution to this problem. hence, our invention regarding novel radiopaque biocompatible polymers has tremendous commercial value in immediate future. the invention also concerns the antibacterial property which could be used as skin grafts, dental applications, etc. who have made contribution towards this project and specific detail i.e. student team, faculty, mentor, anyone else. (100 words) : student team: paulomi ghosh, arun prabhu rameshbabu faculty: dr, santanu dhara synopsis / abstract of innovation (600 words): in the present study, we pursued iodination of the olefinic units of a crosslinker followed by their cross-linking with amine/hydroxyl moieties of polymer to form radiopaque derivatives. the opacity of the radiopaque derivatives was comparable to aluminum of equivalent thickness and commercially available radiopaque tape. the crosslinking precursor may be any molecule that opens at an elevated temperature to form a crosslinking agent with ethylene and multi-aldehyde functionalities. in a preferred embodiment of the invention, the crosslinker employed is 2,5 dimethoxy 2,5 dihydrofuran (dhf) which is a low molecular weight, non-toxic, environmentally friendly crosslinker. the crosslinking kinetics can be manipulated by controlling temperature, ph and concentration of dhf. under optimal conditions only, dhf ring opens to form butenedial, a dialdehyde. the ethylene moieties of dhf were employed to introduce iodine via nucleophilic substitution reaction forming covalently bonded iodinated crosslinker. the dialdehydes of iodinated crosslinkers could be crosslinked with any substance having amine or amide functionalities that includes but not restricted to proteins, aminopolysaccharide, polymer (natural/synthetic origin) leading to formation of covalent imine (c=n) bond. the said invention is a platform technology for multiple products which is enlisted below. 1. x-ray visibility of implants is important to orthopaedic surgeon for real time monitoring during vertebroplasty, knee/ hip arthroplasty and as bone cement to detect possible leakages. 2. the invention also relates to surgical swabs, sponges, gauze consisting of non woven fibers wherein the entangled fibers are x-ray visible in nature. earlier barium sulphate was used as x-ray detectable material in conjunction with surgical sponges; however concerns relating to toxicity became apparent. accordingly, the object of the present invention was covalently bonded that endowed safety as well as x-ray visibility. 3. in use, a stent is situated to define an open sided space corresponding to precise tissue morphology. a requirement for any clinically useful stent is that it should have good visibility under fluoroscopic x-ray illumination so that the position of the stent during the implantation procedure is visible to the physician performing the procedure. to make the stents visible in an x-ray, radiopaque markers typically of gold or tantalum are typically attached onto the stent using a number of techniques. a disadvantage with the current radiopaque marker technology is that, when viewed under fluoroscopic illumination, the radiopaque markers may provide poor or no indication of whether the stent is fully extended. in contrast, the product described is nontoxic and allows monitoring in a non-invasive manner. 4. in another embodiment of the invention, the introduction of iodine in polymer conferred antimicrobial property. antibacterial and radiopaque properties find use as skin constructs and in dental fillings. 5. blood flow distributions throughout the body and within organs are estimated using deposition markers wherein the deposition markers are administered to the tissues. organ tissue perfusion measurements have been performed with computerized tomography (ct) following introduction of a soluble contrast agent in tissues. however, problems including partial diffusion of the contrast agent into the tissue and their settling properties and leakages in other tissues persist. the use of radiopaque microspheres in this endeavor may solve the problem. radiopaque microspheres may be injected into a tissue followed by ct imaging to provide an indication of organ tissue perfusion. 6. also, the said invention finds use as radio protective clothings such as gloves, apron, to be worn by workers, doctors and technician exposed to x-rays. 7.since the iodinated crosslinker is in liquid state they can be employed to print small characters such as symbols, letters, and numbers on medical appliances. also they can be used as barcode to track high security products.

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Project Details :
  • Date : Dec 27,2014
  • Innovator : paulomi ghosh
  • Team Members : Dr. Santanu Dhara, Mr. Arun Prabhu Rameshbabu
  • Guide Name : Dr. Santanu Dhara
  • College : School of Medical Science and Technology, Indian Institute of Technology Kharagpur
  • University : Indian Institute of Technology Kharagpur
  • Submission Year : 2015
  • Category : Biomedical Engineering
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